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Madras et al (2006) in a modern paper shown in vivo binding of modafinil to striatal DAT and thalamic Internet in rhesus monkeys employing PET imaging. The investigators as opposed binding from the DAT probe [11C]CFT as well as the Internet probe [11C]MeNER from the absence of modafinil with the binding of these probes in the presence of modafinil